diff --git a/datasette/filters.py b/datasette/filters.py
index efe014ae..5897a3ed 100644
--- a/datasette/filters.py
+++ b/datasette/filters.py
@@ -77,6 +77,20 @@ class InFilter(Filter):
         return "{} in {}".format(column, json.dumps(self.split_value(value)))
 
 
+class NotInFilter(InFilter):
+    key = "notin"
+    display = "not in"
+
+    def where_clause(self, table, column, value, param_counter):
+        values = self.split_value(value)
+        params = [":p{}".format(param_counter + i) for i in range(len(values))]
+        sql = "{} not in ({})".format(escape_sqlite(column), ", ".join(params))
+        return sql, values
+
+    def human_clause(self, column, value):
+        return "{} not in {}".format(column, json.dumps(self.split_value(value)))
+
+
 class Filters:
     _filters = (
         [
@@ -125,6 +139,7 @@ class Filters:
             TemplatedFilter("like", "like", '"{c}" like :{p}', '{c} like "{v}"'),
             TemplatedFilter("glob", "glob", '"{c}" glob :{p}', '{c} glob "{v}"'),
             InFilter(),
+            NotInFilter(),
         ]
         + (
             [
diff --git a/docs/json_api.rst b/docs/json_api.rst
index 4b365e14..de70362c 100644
--- a/docs/json_api.rst
+++ b/docs/json_api.rst
@@ -228,6 +228,9 @@ You can filter the data returned by the table based on column values using a que
 
     ``?column__in=["value","value,with,commas"]``
 
+``?column__notin=value1,value2,value3``
+    Rows where column does not match any of the provided values. The inverse of ``__in=``. Also supports JSON arrays.
+
 ``?column__arraycontains=value``
     Works against columns that contain JSON arrays - matches if any of the values in that array match.
 
diff --git a/tests/test_filters.py b/tests/test_filters.py
index fd682cd9..8598087f 100644
--- a/tests/test_filters.py
+++ b/tests/test_filters.py
@@ -47,6 +47,9 @@ import pytest
             ["foo in (:p0, :p1)"],
             ["dog,cat", "cat[dog]"],
         ),
+        # Not in, and JSON array not in
+        ((("foo__notin", "1,2,3"),), ["foo not in (:p0, :p1, :p2)"], ["1", "2", "3"]),
+        ((("foo__notin", "[1,2,3]"),), ["foo not in (:p0, :p1, :p2)"], [1, 2, 3]),
     ],
 )
 def test_build_where(args, expected_where, expected_params):