diff --git a/datasette/utils/__init__.py b/datasette/utils/__init__.py
index e17b4d7f..133b9bc7 100644
--- a/datasette/utils/__init__.py
+++ b/datasette/utils/__init__.py
@@ -51,6 +51,7 @@ SPATIALITE_PATHS = (
     "/usr/lib/x86_64-linux-gnu/mod_spatialite.so",
     "/usr/local/lib/mod_spatialite.dylib",
     "/usr/local/lib/mod_spatialite.so",
+    "/opt/homebrew/lib/mod_spatialite.dylib",
 )
 # Used to display /-/versions.json SpatiaLite information
 SPATIALITE_FUNCTIONS = (