diff --git a/.github/workflows/publish.yml b/.github/workflows/publish.yml
index 17c6ae9b..3cfc67da 100644
--- a/.github/workflows/publish.yml
+++ b/.github/workflows/publish.yml
@@ -9,7 +9,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: ["3.6", "3.7", "3.8", "3.9", "3.10"]
+        python-version: ["3.7", "3.8", "3.9", "3.10"]
     steps:
     - uses: actions/checkout@v2
     - name: Set up Python ${{ matrix.python-version }}
@@ -38,7 +38,7 @@ jobs:
     - name: Set up Python
       uses: actions/setup-python@v2
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - uses: actions/cache@v2
       name: Configure pip caching
       with:
@@ -66,7 +66,7 @@ jobs:
     - name: Set up Python
       uses: actions/setup-python@v2
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - uses: actions/cache@v2
       name: Configure pip caching
       with:
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 704931a6..78c289bb 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -7,7 +7,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: ["3.6", "3.7", "3.8", "3.9", "3.10"]
+        python-version: ["3.7", "3.8", "3.9", "3.10"]
     steps:
     - uses: actions/checkout@v2
     - name: Set up Python ${{ matrix.python-version }}
diff --git a/README.md b/README.md
index ce15ccf4..107d81da 100644
--- a/README.md
+++ b/README.md
@@ -35,7 +35,7 @@ You can also install it using `pip` or `pipx`:
 
     pip install datasette
 
-Datasette requires Python 3.6 or higher. We also have [detailed installation instructions](https://docs.datasette.io/en/stable/installation.html) covering other options such as Docker.
+Datasette requires Python 3.7 or higher. We also have [detailed installation instructions](https://docs.datasette.io/en/stable/installation.html) covering other options such as Docker.
 
 ## Basic usage
 
diff --git a/docs/contributing.rst b/docs/contributing.rst
index 07f2a0e4..b74f2f36 100644
--- a/docs/contributing.rst
+++ b/docs/contributing.rst
@@ -19,7 +19,7 @@ General guidelines
 Setting up a development environment
 ------------------------------------
 
-If you have Python 3.6 or higher installed on your computer (on OS X the quickest way to do this `is using homebrew <https://docs.python-guide.org/starting/install3/osx/>`__) you can install an editable copy of Datasette using the following steps.
+If you have Python 3.7 or higher installed on your computer (on OS X the quickest way to do this `is using homebrew <https://docs.python-guide.org/starting/install3/osx/>`__) you can install an editable copy of Datasette using the following steps.
 
 If you want to use GitHub to publish your changes, first `create a fork of datasette <https://github.com/simonw/datasette/fork>`__ under your own GitHub account.
 
diff --git a/docs/installation.rst b/docs/installation.rst
index ac3dcca2..e8bef9cd 100644
--- a/docs/installation.rst
+++ b/docs/installation.rst
@@ -56,7 +56,7 @@ If the latest packaged release of Datasette has not yet been made available thro
 Using pip
 ---------
 
-Datasette requires Python 3.6 or higher. Visit `InstallPython3.com <https://installpython3.com/>`__ for step-by-step installation guides for your operating system.
+Datasette requires Python 3.7 or higher. Visit `InstallPython3.com <https://installpython3.com/>`__ for step-by-step installation guides for your operating system.
 
 You can install Datasette and its dependencies using ``pip``::
 
diff --git a/docs/introspection.rst b/docs/introspection.rst
index d1a0a854..e08ca911 100644
--- a/docs/introspection.rst
+++ b/docs/introspection.rst
@@ -38,11 +38,11 @@ Shows the version of Datasette, Python and SQLite. `Versions example <https://la
 
     {
         "datasette": {
-            "version": "0.21"
+            "version": "0.60"
         },
         "python": {
-            "full": "3.6.5 (default, May  5 2018, 03:07:21) \n[GCC 6.3.0 20170516]",
-            "version": "3.6.5"
+            "full": "3.8.12 (default, Dec 21 2021, 10:45:09) \n[GCC 10.2.1 20210110]",
+            "version": "3.8.12"
         },
         "sqlite": {
             "extensions": {
@@ -62,7 +62,7 @@ Shows the version of Datasette, Python and SQLite. `Versions example <https://la
                 "ENABLE_RTREE",
                 "THREADSAFE=1"
             ],
-            "version": "3.16.2"
+            "version": "3.37.0"
         }
     }
 
diff --git a/setup.py b/setup.py
index e9ef082a..dade0a88 100644
--- a/setup.py
+++ b/setup.py
@@ -40,7 +40,7 @@ setup(
     packages=find_packages(exclude=("tests",)),
     package_data={"datasette": ["templates/*.html"]},
     include_package_data=True,
-    python_requires=">=3.6",
+    python_requires=">=3.7",
     install_requires=[
         "asgiref>=3.2.10,<3.5.0",
         "click>=7.1.1,<8.1.0",
@@ -91,6 +91,5 @@ setup(
         "Programming Language :: Python :: 3.9",
         "Programming Language :: Python :: 3.8",
         "Programming Language :: Python :: 3.7",
-        "Programming Language :: Python :: 3.6",
     ],
 )