diff --git a/datasette/app.py b/datasette/app.py
index 052131d0..0307828e 100644
--- a/datasette/app.py
+++ b/datasette/app.py
@@ -430,8 +430,46 @@ class Datasette:
             self.executor, sql_operation_in_thread
         )
 
-    def app(self):
-        app = Sanic(__name__)
+    def asgi_app(self):
+        self.configure_jinja()
+        from starlette.routing import Router, Path, PathPrefix
+        from starlette.staticfiles import StaticFile, StaticFiles
+        return Router([
+            Path(
+                '/(?P<as_format>\.jsono?)?$',
+                app=IndexView(self).asgi_app(),
+                methods=['GET']
+            ),
+            Path(
+                '/favicon.ico',
+                app=StaticFile(
+                    path=str(app_root / "datasette" / "static" / "favicon.ico")
+                )
+            ),
+            PathPrefix(
+                '/-/static/',
+                app=StaticFiles(
+                    directory=str(app_root / "datasette" / "static")
+                )
+            ),
+            Path(
+                "/(?P<db_name>[^/]+?)(?P<as_format>(\.jsono?|\.csv))?$",
+                app=DatabaseView(self).asgi_app(),
+            ),
+            Path(
+                "/(?P<db_name>[^/]+?)/(?P<table_and_format>[^/]+?)$",
+                app=TableView(self).asgi_app(),
+            ),
+        ])
+        # app.add_route(
+        #     DatabaseView.as_view(self), "/<db_name:[^/]+?><as_format:(\.jsono?|\.csv)?$>"
+        # )
+        # app.add_route(
+        #     TableView.as_view(self),
+        #     "/<db_name:[^/]+>/<table_and_format:[^/]+?$>",
+        # )
+
+    def configure_jinja(self):
         default_templates = str(app_root / "datasette" / "templates")
         template_paths = []
         if self.template_dir:
@@ -459,6 +497,10 @@ class Datasette:
         self.jinja_env.filters["escape_sqlite"] = escape_sqlite
         self.jinja_env.filters["to_css_class"] = to_css_class
         pm.hook.prepare_jinja2_environment(env=self.jinja_env)
+
+    def app(self):
+        app = Sanic(__name__)
+        self.configure_jinja()
         app.add_route(IndexView.as_view(self), "/<as_format:(\.jsono?)?$>")
         # TODO: /favicon.ico and /-/static/ deserve far-future cache expires
         app.add_route(favicon, "/favicon.ico")
diff --git a/datasette/cli.py b/datasette/cli.py
index 820367ac..a9e69877 100644
--- a/datasette/cli.py
+++ b/datasette/cli.py
@@ -256,6 +256,9 @@ def package(
     "-h", "--host", default="127.0.0.1", help="host for server, defaults to 127.0.0.1"
 )
 @click.option("-p", "--port", default=8001, help="port for server, defaults to 8001")
+@click.option(
+    "--asgi", is_flag=True, help="Run in ASGI mode"
+)
 @click.option(
     "--debug", is_flag=True, help="Enable debug mode - useful for development"
 )
@@ -316,6 +319,7 @@ def serve(
     files,
     host,
     port,
+    asgi,
     debug,
     reload,
     cors,
@@ -372,4 +376,9 @@ def serve(
     )
     # Force initial hashing/table counting
     ds.inspect()
-    ds.app().run(host=host, port=port, debug=debug)
+    if asgi:
+        import uvicorn
+        app = ds.asgi_app()
+        uvicorn.run(app, host, port, log_level="info")
+    else:
+        ds.app().run(host=host, port=port, debug=debug)
diff --git a/datasette/views/base.py b/datasette/views/base.py
index 45bc8183..2e2d981d 100644
--- a/datasette/views/base.py
+++ b/datasette/views/base.py
@@ -12,6 +12,8 @@ from sanic import response
 from sanic.exceptions import NotFound
 from sanic.views import HTTPMethodView
 
+from starlette import asgi_application, Response
+
 from datasette import __version__
 from datasette.utils import (
     CustomJSONEncoder,
@@ -43,8 +45,45 @@ class DatasetteError(Exception):
         self.messagge_is_html = messagge_is_html
 
 
+class RequestWrapper:
+    # Implements the subset of the Sanic request that my code uses
+    def __init__(self, starlette_request):
+        self._request = starlette_request
+
+    @property
+    def path(self):
+        return self._request.url.path
+
+    @property
+    def query_string(self):
+        return str(self._request._scope["query_string"])
+
+    @property
+    def args(self):
+        # Key/list-of-values
+        # There's probably a better way to do this:
+        d = {}
+        for key, value in self._request.query_params:
+            d.setdefault(key, []).append(value)
+        return d
+
+    @property
+    def raw_args(self):
+        # Flat key/first-value dictionary
+        return dict(self.args)
+
+
 class RenderMixin(HTTPMethodView):
 
+    def asgi_app(self):
+        @asgi_application
+        async def app(request):
+            sanic_response = await self.get(
+                RequestWrapper(request), **request["kwargs"]
+            )
+            return Response(sanic_response.body)
+        return app
+
     def render(self, templates, **context):
         template = self.ds.jinja_env.select_template(templates)
         select_templates = [
diff --git a/setup.py b/setup.py
index 4a38faba..c221fbca 100644
--- a/setup.py
+++ b/setup.py
@@ -41,6 +41,8 @@ setup(
         'hupper==1.0',
         'pint==0.8.1',
         'pluggy>=0.1.0,<1.0',
+        'starlette==0.1.15',
+        'uvicorn==0.2.21',
     ],
     entry_points='''
         [console_scripts]