diff --git a/datasette/utils/__init__.py b/datasette/utils/__init__.py
index 0df0a871..f3f4e2bd 100644
--- a/datasette/utils/__init__.py
+++ b/datasette/utils/__init__.py
@@ -1142,7 +1142,7 @@ def format_bytes(bytes):
         return f"{current:.1f} {unit}"
 
 
-_escape_fts_re = re.compile(r'\s+|(".*?")')
+_escape_fts_re = re.compile(r'\s+|(".*?")', re.DOTALL)
 
 
 def escape_fts(query):
diff --git a/tests/test_table_api.py b/tests/test_table_api.py
index 58a5ddc3..38f1cfa3 100644
--- a/tests/test_table_api.py
+++ b/tests/test_table_api.py
@@ -562,6 +562,16 @@ async def test_searchable(ds_client, path, expected_rows):
     assert expected_rows == response.json()["rows"]
 
 
+@pytest.mark.asyncio
+async def test_search_quote_followed_by_newline(ds_client):
+    # A quote followed by a newline used to produce an invalid FTS query
+    response = await ds_client.get(
+        "/fixtures/searchable.json?_shape=arrays&_search=e%22%0A%21"
+    )
+    assert response.status_code == 200
+    assert response.json()["rows"] == []
+
+
 _SEARCHMODE_RAW_RESULTS = [
     [1, "barry cat", "terry dog", "panther"],
     [2, "terry dog", "sara weasel", "puma"],
diff --git a/tests/test_utils.py b/tests/test_utils.py
index 68d4a504..ae536f09 100644
--- a/tests/test_utils.py
+++ b/tests/test_utils.py
@@ -605,6 +605,11 @@ def test_format_bytes(bytes, expected):
         # Sensibly handle unbalanced double quotes
         ('cat"', '"cat"'),
         ('"cat dog" "fish', '"cat dog" "fish"'),
+        # Quoted phrases and unbalanced quotes can contain newlines
+        ('"cat\ndog"', '"cat\ndog"'),
+        ('"cat\ndog" fish', '"cat\ndog" "fish"'),
+        ('cat "dog\nfish', '"cat" "dog\nfish"'),
+        ('cat"\n!', '"cat" "\n!"'),
     ],
 )
 def test_escape_fts(query, expected):