diff --git a/sqlite_utils/db.py b/sqlite_utils/db.py
index 08dbb1d..5c14738 100644
--- a/sqlite_utils/db.py
+++ b/sqlite_utils/db.py
@@ -1,5 +1,6 @@
 import sqlite3
 from collections import namedtuple
+import datetime
 import json
 
 Column = namedtuple(
@@ -53,16 +54,20 @@ class Database:
                 key=lambda p: column_order.index(p[0]) if p[0] in column_order else 999
             )
         extra = ""
+        col_type_mapping = {
+            float: "FLOAT",
+            int: "INTEGER",
+            bool: "INTEGER",
+            str: "TEXT",
+            bytes.__class__: "BLOB",
+            bytes: "BLOB",
+            datetime.datetime: "TEXT",
+            None.__class__: "TEXT",
+        }
         columns_sql = ",\n".join(
             "   [{col_name}] {col_type} {primary_key} {references}".format(
                 col_name=col_name,
-                col_type={
-                    float: "FLOAT",
-                    int: "INTEGER",
-                    bool: "INTEGER",
-                    str: "TEXT",
-                    None.__class__: "TEXT",
-                }[col_type],
+                col_type=col_type_mapping[col_type],
                 primary_key=" PRIMARY KEY" if (pk == col_name) else "",
                 references=(
                     " REFERENCES [{other_table}]([{other_column}])".format(
@@ -252,6 +257,8 @@ class Table:
                 t = int
             elif {int, float, bool}.issuperset(types):
                 t = float
+            elif {bytes, str}.issuperset(types):
+                t = bytes
             else:
                 t = str
             column_types[key] = t
diff --git a/tests/test_create.py b/tests/test_create.py
index 578ee56..67071ae 100644
--- a/tests/test_create.py
+++ b/tests/test_create.py
@@ -1,5 +1,6 @@
 from sqlite_utils.db import Index
 import collections
+import datetime
 import pytest
 import json
 
@@ -8,7 +9,14 @@ def test_create_table(fresh_db):
     assert [] == fresh_db.table_names
     table = fresh_db.create_table(
         "test_table",
-        {"text_col": str, "float_col": float, "int_col": int, "bool_col": bool},
+        {
+            "text_col": str,
+            "float_col": float,
+            "int_col": int,
+            "bool_col": bool,
+            "bytes_col": bytes,
+            "datetime_col": datetime.datetime,
+        },
     )
     assert ["test_table"] == fresh_db.table_names
     assert [
@@ -16,6 +24,8 @@ def test_create_table(fresh_db):
         {"name": "float_col", "type": "FLOAT"},
         {"name": "int_col", "type": "INTEGER"},
         {"name": "bool_col", "type": "INTEGER"},
+        {"name": "bytes_col", "type": "BLOB"},
+        {"name": "datetime_col", "type": "TEXT"},
     ] == [{"name": col.name, "type": col.type} for col in table.columns]